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Vitamin D is a fat soluble vitamin with hormonal properties, plays crucial functions in bone and mineral metabolism and has important regulatory functions in brain development, cell differentiation and apoptosis. There are associations between vitamin D deficiency and a number of neurological and psychological conditions. In this study, we investigated the relationship between headache and vitamin D deficiency in pediatric patients suffering from headache, and considered the effect of high solar-exposure (HSE) and low solar-exposure (LSE).
Materials and methods
In this study, 150 patients with headache and 101 healthy controls (5–16 years of age) were evaluated. Patient data were investigated retrospectively and included the following measures: physical examination, EEG, neuroimaging studies, Calcium, Phosphor, Alkaline phosphates, Parathyroid hormone, and 25-OH Vitamin D levels. Patient and control groups were divided into two separate sub-groups based on presentation to the clinic in either LSE or HSE months.
25-OH Vitamin D levels of the group with headache and headache subtypes (migraine, tension-type headache) were significantly lower than that of the control group (17.09±9.46, 17.35±9.02, 16.99±9.91 and 38±12.80, respectively p<0.05). This difference was also seen in HSE and LSE groups (p<0.05). Furthermore, levels were lower in migraine patients than in control group in HSE and in the tension-type headache group in LSE (p<0.05).
There is a relationship between vitamin D deficiency and headache, with particular significance in LSE. Therefore, vitamin D deficiency should be evaluated when investigating headache in children.
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© 2015 European Paediatric Neurology Society. Published by Elsevier Inc. All rights reserved.